Each 100 gm contain 20
Chloramphenicol is abroad spectrum antibiotic active
against Gm+ve, Gm-ve bacteria, spirochaetes and
After administration within 2 hrs. blood levels of it is
increased, which are mintained for at least 24 hrs.
Gastroenteritis, pneumoina, polyarthritis,
metritis, infections of urinary tract and infectious
1- Hypersensitivity to chloramphenicol, in
newborns, liver dysfunction.
2- Not administered during gestation and
3- Not used in cases of mastitis.
Long term treatment
may cause reversible depression of hematopieosis,
intestinal disturbances and seldom an irreversable bone
marrow toxicity resulting in fatal aplastic anemia.
1- Chloramphenicol can inhibit the hepatic
metabolism of several drugs including phenobarbital and
2- Possible antagonism with bactericide
antibiotic such as Penicillin, Amino glycosides and
3- Rifampin may decrease serum Chloramphenicol
40 - 80 mg./kgm. body
1- Meat 3 weeks.
2- Milk 3 days.
200 gm, 500 gm
Cool dry place away
from direct sunlight.
1- Stability 2-3 years.
2- Medicated water
should be supplied within 24 hrs.